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UpToDate Database User Guide

UpToDate® is an evidence-based, physician-authored clinical decision support resource which clinicians trust to make the right point-of-care decisions. More than 5,100 world-renowned physician authors, editors and peer reviewers use a rigorous editorial p

What is Lexicomp?

lexicomp drug interactions logo

Lexicomp Drug Interactions combines medical literature and scientific understanding of drug interactions in an electronic platform, providing an efficient way to inform professionals about adverse drug events that could compromise the care of patients.

Accessing Lexicomp through UpToDate

Lexicomp drug information is directly integrated into UpToDate. 

Go to UpToDate and enter a drug name in the New Search box and click SearchNotice your results display the generic drug name:

Click a record to view the Lexicomp information. From the record, you will also see a link that allows you to access additional results in Lexicomp Online:

Searching Lexicomp

In addition to having access to Lexicomp Online, you can also directly search Lexi-Interact to view drug interactions. 

Under the UpToDate search box, click Drug Interactions:

drug interactions

Enter two or more drug names to see how they interact:

lexicomp drug interactions search bar

Your results will tell you whether there is a significant interaction between the drugs.

lexicomp drug interactions results

Lexicomp Risk Rating

X: Avoid Combination

D: Consider Therapy Modification

C: Monitor Therapy

B: No Needed Action

A: No Known Interaction

lexicomp risk ratings explanations

Finding Fulltext in Lexicomp

When viewing an article, scroll down to References, and click the PubMed ID number to see if the full-text article is available:

If the article is not available or you're prompted to pay, copy & paste the citation information into Article Finder.